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. 2000 Jun;156(6):2091–2101. doi: 10.1016/S0002-9440(10)65080-8

Figure 5.

Figure 5.

Effect of NS-398 on PGE2 generation in glomeruli isolated from normal rats and rats with PHN (day 14). Glomeruli were prepared as in Figure 4 ▶ . A: Glomeruli were incubated in vitro with NS-398 (10−7 M) or vehicle (dimethylsulfoxide) for 15 minutes, and PGE2 released into the buffer was measured by radioimmunoassay. Values are mean ± SEM of 3 control rats and 5 rats with PHN. Significant differences were present among groups (P < 0.005 ANOVA; *P < 0.01 PHN versus control, **P = 0.02 PHN versus PHN+NS-398). B: Glomeruli were incubated as in A, except NS-398 was added at 10−5 M. Values are mean ± SEM of 4 control rats and 8 rats with PHN. Significant differences were present among groups: P < 0.0001 ANOVA; *P < 0.0001 PHN versus control, **P = 0.0001 PHN versus PHN+NS-398, ***P = 0.0006 control versus control+NS-398.