Table 1.
Echocardiographic cardiac performance parameters for R6/2 mice and littermate controls
| 8 WEEKS | 10 WEEKS | 12 WEEKS | ||||
|---|---|---|---|---|---|---|
| CTRL | HD | CTRL | HD | CTRL | HD | |
| Heart Rate (beats per minute) | 498±43 | 458±26 | 500±34 | 482±22 | 488±27 | 467±15 |
| LVIDs (cm) | 0.161±0.005 | 0.158±0.004 | 0.165±0.009 | 0.189±0.007* | 0.142±0.008 | 0.176±.0.008* |
| LVIDd (cm) | 0.312±0.007 | 0.310±0.006 | 0.304±0.010 | 0.305±0.007 | 0.303±0.013 | 0.286±0.008 |
| Peak aortic flow (cm/s) | 118.8±4.2 | 106.1±4.8 | 117.2±3.9 | 104.5±4.4* | 126.2±7.7 | 78.9±2.3* |
| Aortic VTI (cm) | 6.2±0.18 | 4.55±0.18 | 5.55±0.18 | 4.60±0.34* | 6.26±0.30 | 3.86±0.20* |
| Aortic acceleration slope (cm/s2) | 5060.5±417.8 | 5082.8±464.6 | 4378.9±351.9 | 4190.0±449.3 | 5652.7±514.0 | 3493.7±295.3* |
| Aortic deceleration slope (cm/s2) | 2530.0±331.9 | 2375.3±287.7 | 2415.2±177.9 | 2153.0±164.2 | 2910.3±200.2 | 1405.2±69.7* |
| E wave VTI (cm) | 3.04±0.20 | 2.09±0.10* | 3.21±0.18 | 2.20±0.25* | 3.80±0.39 | 2.30±0.07* |
| E wave acceleration slope (cm/s2) | 5914.5±378.0 | 4770.0±452.2* | 6282.2±388.2 | 3581.6±482.1* | 7397.2±271.4 | 5577.2±194.7* |
| E wave deceleration slope (cm/s2) | 3306.6±257.3 | 3997.3±224.7 | 3246.5±235.7 | 1767.0±329.8* | 3672.7±409.1 | 2521.3±249.6* |
| A wave VTI (cm) | 1.21±0.07 | 2.04±0.07* | 0.86±0.05 | 1.18±0.11* | 1.23±0.15 | 1.88±0.22* |
| A wave acceleration slope (cm/s2) | 1958.3±332.1 | 1400.0±91.3 | 1391.0±164.4 | 929.0±117.7* | 1841.4±310.6 | 1794.1±218.9 |
| A wave deceleration slope (cm/s2) | 973.0±68.6 | 1088.3±32.2 | 875.8±73.2 | 616.3±54.1* | 1053.6±81.0 | 1278.3±192.5 |
*
= p<0.05 versus littermate control