Table 2.

Expression of HIF-1α and HIF-2α within Tumor Cell Nuclei

Tumor type	No. of cases	HIF-1α and HIF-2α positive	HIF-1α-positive only	HIF-2α-positive only	HIF-1α and HIF-2α negative
Bladder adenocarcinoma	5	2	0	0	3
Glioblastoma multiforme	5	2	0	0	3
Breast adenocarcinoma	12	10	0	1	1
Colon adenocarcinoma	5	4	0	0	1
Hepatocellular carcinoma	5	2	0	0	3
Hypernephroma	5	2	2	0	1
Lung tumors (squamous cell, adenocarcinoma)	5	0	0	0	5
Ovarian adenocarcinoma	5	5	0	0	0
Pancreatic adenocarcinoma	3	2	0	1	0
Prostatic adenocarcinoma	5	2	0	1	2
Buffy coat chronic myeloid leukemia	2	0	0	0	2
Totals	57	31	2	3	21

In addition, HIF-2α expression was detected within subsets of tumor-associated macrophages in all cases.