Figure 2.

Positive cytoplasmic staining of clusterin in invasive breast carcinomas by immunohistochemistry and in situ hybridization. A and B: Immunoreactivity of clusterin in a lobular carcinoma (original magnifications: ×50 and ×400). C and D: In situ hybridization analysis of clusterin mRNA in poorly (C) and moderately (D) differentiated ductal carcinomas (both ×400). E and F: Lymph node metastasis of an infiltrating ductal carcinoma (×100 and ×400). All sections were counterstained with hematoxylin.