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Immunochemical measurements of phosphorylated tau using mAb AT8 in the sarkosyl-insoluble fraction and in the soluble tau fraction from frontal and temporal cortex with respect to Braak stage. The first statistically significant deviation relative to the preceding stage(s) occurred at stage 4 for sarkosyl-insoluble phosphorylated tau, and in the comparison grouping stages 5 and 6 for soluble phosphorylated tau.
