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Immunochemical measurements of three synaptic proteins in frontal and temporal cortex with respect to Braak stage. The first statistically significant deviation relative to the preceding stage(s) occurred at stage 3 for all three proteins. In the comparison of stages 4 to 6 with respect to stage 3, only the decline in syntaxin reached statistical significance, although the declines in synaptophysin and SNAP-25 were close to the significance criterion (P < 0.06).
