Table 3.
Analysis of Variance in Biochemical and Neuropathological Changes in Neocortex with Respect to Clinical Severity (CAMDEX)
| CLINSEV | Parameter | df | Error | F | P | Mean diff. | C.I. | ||
|---|---|---|---|---|---|---|---|---|---|
| 0,1,2,3,4 | PHF-tau | 423 | 4 | 4.80 | 7.89 | 0.000 | |||
| 7.51 | 4 | 4.59 | 10.38 | 0.000 | |||||
| AT8 | 4 | 3.45 | 8.97 | 0.000 | |||||
| Phosphorylated tau | Sarkosyl AT8 | 4 | 2.96 | 7.01 | 0.000 | ||||
| Soluble AT8 | 4 | 0.81 | 3.24 | 0.017 | |||||
| Synaptic proteins | Synaptophysin | 4 | 443.54 | 4.58 | 0.002 | ||||
| Syntaxin | 4 | 635.18 | 3.09 | 0.021 | |||||
| SNAP-25 | 4 | 303.29 | 4.88 | 0.002 | |||||
| α-Synuclein | 4 | 946.21 | 0.94 | 0.446 | |||||
| MAP2 | S1C | 4 | 194.26 | 1.11 | 0.360 | ||||
| Pathology | Tangles | 4 | 0.38 | 15.40 | 0.000 | ||||
| Neuritic plaques | 4 | 0.28 | 8.42 | 0.000 | |||||
| Aβ Plaques | 4 | 1.57 | 3.81 | 0.007 | |||||
| 0 v 1 | PHF-tau | 423 | 1 | 2.66 | 4.77 | 0.035 | 1.18 | −0.39 | 2.75 |
| 7.51 | 1 | 3.23 | 7.52 | 0.009 | 1.63 | 0.15 | 3.12 | ||
| AT8 | 1 | 2.03 | 9.94 | 0.003 | 1.49 | 0.13 | 2.85 | ||
| Phosphorylated tau | Sarkosyl AT8 | 1 | 2.64 | 0.44 | 0.511 | 0.36 | −0.97 | 1.69 | |
| Soluble AT8 | 1 | 0.49 | 3.61 | 0.065 | 0.44 | −0.03 | 0.90 | ||
| Synaptic proteins | Synaptophysin | 1 | 423.24 | 0.06 | 0.809 | −1.66 | −15.84 | 12.52 | |
| Syntaxin | 1 | 433.86 | 0.03 | 0.875 | 1.09 | −13.03 | 15.21 | ||
| SNAP-25 | 1 | 237.77 | 0.43 | 0.517 | −3.34 | −13.60 | 6.92 | ||
| α-Synuclein | 1 | 709.77 | 0.81 | 0.375 | −7.94 | −21.23 | 5.35 | ||
| MAP2 | S1C | 1 | 220.36 | 1.47 | 0.233 | −7.83 | −21.80 | 6.15 | |
| Pathology | Tangles | 1 | 0.13 | 7.80 | 0.008 | 0.33 | 0.01 | 0.67 | |
| Neuritic plaques | 1 | 0.07 | 7.25 | 0.011 | 0.24 | −0.03 | 0.51 | ||
| Aβ Plaques | 1 | 1.83 | 6.04 | 0.019 | 1.10 | 0.19 | 2.01 | ||
| 0,1 v 2 | PHF-tau | 423 | 1 | 4.31 | 15.50 | 0.000 | 2.32 | 0.76 | 3.88 |
| 7.51 | 1 | 4.50 | 16.98 | 0.000 | 2.48 | 1.09 | 3.87 | ||
| AT8 | 1 | 3.31 | 9.03 | 0.004 | 1.55 | 0.23 | 2.88 | ||
| Phosphorylated tau | Sarkosyl AT8 | 1 | 2.46 | 19.43 | 0.000 | 1.96 | 1.01 | 2.91 | |
| Soluble AT8 | 1 | 0.71 | 5.32 | 0.025 | 0.55 | −0.02 | 1.12 | ||
| Synaptic proteins | Synaptophysin | 1 | 500.98 | 3.96 | 0.052 | 12.64 | −1.72 | 26.99 | |
| Syntaxin | 1 | 676.67 | 2.40 | 0.127 | 11.45 | −7.26 | 30.15 | ||
| SNAP-25 | 1 | 332.54 | 5.59 | 0.022 | 12.23 | −0.39 | 24.85 | ||
| α-Synuclein | 1 | 987.66 | 0.66 | 0.419 | 7.27 | −14.16 | 28.69 | ||
| MAP2 | S1C | 1 | 208.89 | 0.35 | 0.559 | 0.10 | −6.66 | 6.87 | |
| Pathology | Tangles | 1 | 0.24 | 21.11 | 0.000 | 0.64 | 0.28 | 1.00 | |
| Neuritic plaques | 1 | 0.14 | 8.23 | 0.006 | 0.31 | 0.03 | 0.59 | ||
| Aβ Plaques | 1 | 1.82 | 2.77 | 0.102 | 0.64 | −0.06 | 1.33 | ||
| 0,1,2 v 3 | PHF-tau | 423 | 1 | 5.99 | 4.09 | 0.047 | 1.47 | −0.46 | 3.41 |
| 7.51 | 1 | 5.94 | 7.46 | 0.008 | 1.98 | 0.27 | 3.69 | ||
| AT8 | 1 | 4.11 | 10.91 | 0.002 | 1.99 | 0.32 | 3.66 | ||
| Phosphorylated tau | Sarkosyl AT8 | 1 | 3.71 | 2.03 | 0.159 | 0.82 | −0.65 | 2.28 | |
| Soluble AT8 | 1 | 0.90 | 3.24 | 0.077 | 0.51 | −0.23 | 1.25 | ||
| Synaptic proteins | Synaptophysin | 1 | 465.16 | 12.62 | 0.001 | −22.81 | −32.73 | −12.89 | |
| Syntaxin | 1 | 667.95 | 6.35 | 0.014 | −19.40 | −34.68 | −4.11 | ||
| SNAP-25 | 1 | 333.80 | 9.86 | 0.003 | −17.08 | −26.78 | −7.39 | ||
| α-Synuclein | 1 | 824.65 | 0.10 | 0.756 | −2.67 | −13.03 | 7.70 | ||
| MAP2 | S1C | 1 | 201.98 | 0.71 | 0.404 | 12.46 | 2.96 | 21.97 | |
| Pathology | Tangles | 1 | 0.47 | 11.19 | 0.001 | 0.68 | 0.06 | 1.30 | |
| Neuritic plaques | 1 | 0.30 | 17.21 | 0.000 | 0.68 | 0.12 | 1.24 | ||
| Aβ Plaques | 1 | 1.81 | 0.71 | 0.403 | 0.34 | −0.43 | 1.10 | ||
| 0,1,2,3 v 4 | PHF-tau | 423 | 1 | 6.03 | 7.91 | 0.006 | 3.55 | 2.58 | 4.51 |
| 7.51 | 1 | 6.39 | 7.15 | 0.009 | 3.47 | 0.52 | 6.42 | ||
| AT8 | 1 | 4.61 | 6.25 | 0.015 | 2.76 | 0.57 | 4.94 | ||
| Phosphorylated tau | Sarkosyl AT8 | 1 | 3.61 | 7.33 | 0.009 | 2.64 | 1.32 | 3.97 | |
| Soluble AT8 | 1 | 0.89 | 2.29 | 0.134 | 0.73 | 0.48 | 0.98 | ||
| Synaptic proteins | Synaptophysin | 1 | 533.19 | 0.48 | 0.493 | −8.18 | −36.72 | 20.36 | |
| Syntaxin | 1 | 689.62 | 2.87 | 0.095 | −22.85 | −31.92 | −13.77 | ||
| SNAP-25 | 1 | 362.75 | 1.85 | 0.178 | −13.30 | −24.76 | −1.84 | ||
| α-Synuclein | 1 | 925.25 | 2.43 | 0.123 | 24.36 | −68.67 | 117.38 | ||
| MAP2 | S1C | 1 | 193.65 | 1.67 | 0.201 | −6.47 | −12.14 | −0.80 | |
| Pathology | Tangles | 1 | 0.52 | 23.48 | 0.000 | 1.80 | 1.09 | 2.51 | |
| Neuritic plaques | 1 | 0.37 | 7.15 | 0.009 | 0.83 | 0.00 | 1.66 | ||
| Aβ Plaques | 1 | 1.74 | 3.73 | 0.057 | 1.31 | 0.42 | 2.20 | ||