Table 3.

Analysis of MDM2 Protein Isoforms, mRNA and Gene Status in Oral SCCs and Their Relationship with Clinicopathological Features

Case no.	Gender/age (years)	Site	State	HG	Betel and areca nut	Tobacco	MDM2 IHC	MDM2 isoform (kDa)	Subcellular localization	Mdm2 mRNA	Mdm2 amplification (folds)
1	M /60	L	T4N0M0	W	Moderate	–	+1	76	C,M	−	1
2	M /40	BM	T2N0M0	W	Heavy	–	+3	90	N,C	−	1
3	M /54	BM	T4N0M0	W	Heavy	Heavy	+1	57	N	−	1
4	M /70	BM	T2N0M0	W	Heavy	–	+2	90	N,C	−	1
5	F /50	BM	T3N1M0	W	–	Moderate	+2	57	N	−	1
6	M /50	BM	T4N2M0	W	Moderate	–	+3	90	N,C	+	9
7	M /55	P	T4N0M0	W	Heavy	–	+2	57	N	−	1
8	F /45	T	T2N0M0	W	Heavy	–	+2	90	N,C	−	1
9	F /30	BM	T2N0M0	W	–	–	+3	76	C,PM	+	1
10	M /66	BM	T2N0M0	W	Heavy	Heavy	+2	57,90	N,C	−	1
11	M /44	BM	T2N0M0	W	Moderate	–	+1	57	N	−	1
12	M /42	BM	T2N0M0	W	–	Moderate	+1	90	N,C	−	1
13	F /49	BM	T4N1M0	M	–	Moderate	+1	76,90	N,C,PM	−	1
14	M /60	BM	T2N0M0	M	Heavy	Heavy	+2	90	N,C	+	1
15	M /82	P	T4N0M0	M	–	–	+1	76	C,PM	−	1
16	F /59	T	T4N0M0	M	Heavy	–	+3	57	N	−	1
17	F /52	BM	T4N1M0	M	–	Heavy	+2	76	C,PM	−	1
18	M /52	BM	T3N1M0	M	Heavy	–	+3	57	N	−	1
19	M /45	T	T2N1M0	P	Heavy	–	+2	57	N	−	1
20	F /22	BM	T3N1M0	P	Moderate	Moderate	+2	76,90	N,C,PM	−	1