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Bronchiolization 21 days after bleomycin treatment. a: In fibrotic regions of gelatinase B+/+ lung, clusters of cuboidal bronchiolar-appearing epithelium were prominent adjacent to bronchioles or at their distal termination (“bronchiolization”). b: Alveolar bronchiolization was rarely observed in the gelatinase B−/− lung. c: Bronchiolization was present in the matrilysin−/− lung. (elastica-Masson Goldner stain; original magnification, ×400)
