Table 2.
Tissue Involvement by WERI-Rb Retinoblastoma in Mice
| Site | Weeks | |||||||
|---|---|---|---|---|---|---|---|---|
| 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | |
| Vitreous | +2 /2 | +2 /2 | +2 /2 | +2 /2 | +4 /4 | +5 /5 | +2 /2 | +1 /1 |
| Retina | − | − | +1 /2 | +2 /2 | +4 /4 | +5 /5 | +2 /2 | +1 /1 |
| Subretinal space | − | − | − | − | +3 /4 | +4 /5 | +2 /2 | +1 /1 |
| Iris | − | − | − | +2 /2 | +2 /4 | +4 /5 | +2 /2 | +1 /1 |
| Lens | − | − | − | +1 /2 | +2 /4 | +2 /5 | +1 /2 | +1 /1 |
| Anterior chamber | − | − | − | +1 /2 | +2 /4 | +4 /5 | +2 /2 | +1 /1 |
| Choroid | − | − | − | − | +3 /4 | +3 /5 | +2 /2 | +1 /1 |
| Optic nerve | − | − | − | − | − | − | − | − |
| Extraocular | − | − | − | − | − | − | +1 /2 | +1 /1 |
| Brain | − | − | − | − | − | − | − | − |
| Contralateral eye | − | − | − | − | − | − | − | − |
Mice were necropsied and the tissues examined histologically as described in Methods. The data are expressed as the number of animals that were positive for tumor at each site/total number of animals examined.
−, tissues without evidence of tumor in any of the examined animals.