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Expression of SHP-1 protein leads to dephosphorylation of Jak3. T-cell lymphoma lines treated with 5-deoxycitidyne were examined for expression of SHP-1 protein (A) and tyrosine phosphorylation of IL-2R-associated Jak3 kinase before (−) and after (+) stimulation with IL-2 (B). Detection of Jak3 kinase expression (C) served as control for the latter experiment.
