Figure 2.

A: Representative examples of CGH for chromosome 12 on two seminomas without 12p amplification (left) and two with a homogeneous restricted 12p amplification (right). Note that the seminomas with an amplification also show gain of the complete short arm of this chromosome. The number of metaphase spreads analyzed is indicated. B: Representative example of banding (left) and spectral karyotyping (real color at the right, and false color in the middle) of a chromosome 12 derivative known to contain restricted 12p amplification (as determined by in situ hybridization and CGH). Note that the chromosome is composed of chromosome 12 material (indicated in purple), except the most distal region of the p arm, showing chromosome 20-specific material (indicated in blue).