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Representative examples of the presence of DNA laddering after electrophoresis (indicative for apoptosis) of 1-μg high molecular weight DNA isolated from primary seminomas with and without a restricted 12p amplification/RAS mutation. Note the correlation between less apoptosis and the presence of a restricted 12p amplification or RAS mutation. In addition, the results of in vitro culture of the tumor cells are shown (see also Table 3 ▶ ).
