Table 1.
Results of Detection of the Restricted 12p Amplification Using Methanol/Acetic Acid-Fixed Nuclei Suspensions of a Consecutive Series of Primary Seminomas, Nonseminomas, and Combined Tumors as Detected by Double-Fluorescent In Situ Hybridization
| Consecutive series | i(12p) + | Heterogeneity | |||
|---|---|---|---|---|---|
| Tested | +12p amplification | Karyotyping | In situ hybridization | ||
| Seminoma | 46 | 4 (9) | 2/6 | 0/6 | 3/9 |
| Nonseminoma | 23 | 1 (4) | 1/4 | NA | 4/4 |
| Combined tumor | 7 | 1 (2) | 0/1 | NA | 2/2 |
| Total | 76 | 6 (15) | |||
The total numbers of cases with a restricted 12p amplification identified so far are indicated between brackets. The results of karyotyping and in situ hybridization on matched frozen tissue sections are also shown. Abbreviations: +12p amplification, with restricted 12p amplification; NA, not available.