Table 2.
Summary of the Immunohistochemistry (IH) and in Situ Hybridization (ISH) Experiments
| Normal | Dysplastic | Primary tumor | Metastatic | |||||
|---|---|---|---|---|---|---|---|---|
| IH | ISH | IH | ISH | IH | ISH | IH | ISH | |
| Epithelial | 0 /15* | 2 /4 | 3 /3 | 2 /2 | 12 /12 | 4 /4 | 8 /8 | 2 /2 |
| Stromal | 0 /15 | 0 /4 | 0 /3 | 0 /2 | 11 /12 | 3 /4 | 6 /8 | 2 /2 |
| Endothelial | 4 /15 | 3 /4 | 0 /3 | 0 /2 | 10 /12 | 3 /4 | 7 /8 | 2 /2 |
*In some cases (see Discussion) very weak luminal staining in normal epithelial cells neighboring the tumor was observed.
Presented is the ratio between the number of cases in which the cells expressed heparanase in the normal and the progressive stages of neoplasia (dysplasia, primary tumor, and metastasis) and the total number of cases tested for that stage.