Skip to main content
. 2000 Jul;157(1):15–19. doi: 10.1016/S0002-9440(10)64511-7

Figure 2.

Figure 2.

Confocal micrographs of bone marrow biopsy specimens from normal bone marrow or from patients with PV, CML, or MF. Specimens were sectioned to thicknesses of 25–200 μm, then immunostained to reveal microvessels. Stacks of serial optical sections were recorded from regions with the highest vessel density. Single optical sections from four representative serial sections are presented. Bar = 20 μm. A: Confocal micrograph (section 6 of 18) of normal bone marrow shows occasional immunostained microvessels (black), generally straight in nature, occasionally branched, and very rarely tortuous in appearance. B: Confocal micrograph (section 4 of 9) of bone marrow from a patient with polycythemia vera (PV) shows relatively straight, branched immunostained microvessels (black). C: Confocal micrograph (section 7 of 15) of bone marrow from a patient with myelofibrosis (MF), showing numerous short microvessels (black) that appear to be highly branched and tortuous. D: Confocal micrograph (section 6 of 14) of bone marrow of from a patient with chronic myelocytic leukemia (CML), showing immunostained microvessels (black) with numerous branches.