Table 2.
Genes Exhibiting a Differential Expression Pattern between SFK and SFH Cells in Analysis of 597 Arrayed cDNA Clones
| Genes up-regulated or down-regulated in SFK-C cells compared to SFH-C cells | ||
|---|---|---|
| Up-regulation (27 clones) | Down-regulation (15 clones) | |
| c-ErbA proto-oncogene | ZO-1 tight junction protein | |
| Cot proto-oncogene | c-myc proto-oncogene | |
| PDGF receptor α | Cyclin B1 | |
| Golgi 4-transmembrane spanning transporter | *Cyclin D1 | |
| RNA-activating protein kinase inhibitor p58 | Thrombin receptor | |
| *Phosphatidylinositol 3-kinase p85 | Transferrin receptor protein p90 | |
| Glutathione peroxidase | Transcription factor A10 | |
| Microsomal glutathione S-transferase | Matrix metalloproteinase-11 | |
| Mu 1 glutathione S-transferase | MHR23B UV excision repair protein homologue | |
| Pi 1 glutathione S-transferase | Activating transcription factor 4 | |
| Serine proteinase inhibitor SPI3 | *Eps8 receptor tyrosine kinase substrate | |
| Adipocyte differentiation-associated protein | *CD44 | |
| p45 NF-E2-related transcription factor | Vascular cell adhesion molecule-1 | |
| Transcription factor S-II | IGF-binding protein-4 | |
| Monocyte chemoattractant protein-3 | Ornithine decarboxylase | |
| Growth hormone receptor | ||
| Integrin β1 | ||
| IGF-binding protein-3 | ||
| IGF-binding protein-5 | ||
| IGF-binding protein-6 | ||
| *IGF-I | ||
| TGF-β2 | ||
| Cathepsin B | ||
| Cathepsin D | ||
| *Serine protease inhibitor-2.2 | ||
| Serine protease inhibitor-2.4 | ||
| Tissue inhibitor of metalloproteinase-3 | ||
| Genes Up-regulated or Down-regulated in SFH-B Cells Compared to SFH-C Cells | ||
| Up-regulation (25 clones) | Down-regulation (15 clones) | |
| c-myc proto-oncogene | Cot proto-oncogene | |
| Net transcription factor | Cdk4/cdk6 inhibitor p18 | |
| Lfc proto-oncogene | Prothymosin α | |
| Cyclin B2 | Protein kinase C-θ | |
| *Cyclin D1 | *Phosphatidylinositol 3-kinase p85 | |
| Etoposide-induced p53 responsive mRNA | Glutathione reductase | |
| 14-3-3η | Homeobox protein-2.1 | |
| Microsomal glutathione S-transferase | Homeobox protein-8 | |
| Gadd45 | C5A receptor | |
| Serine proteinase inhibitor SPI3 | Cannabinoid receptor 2 | |
| PA6 stromal protein | P-selectin | |
| MHR23B UV excision repair protein homologue | IGF-binding protein-1 | |
| *Eps8 receptor tyrosine kinase substrate | IGF-binding protein-5 | |
| SRY-box containing gene 4 | *IGF-I | |
| Transcription factor SEF2 | FGF-7 | |
| Transcriptional enhancer factor-1 | ||
| YB1 DNA binding protein | ||
| Monocyte chemoattractant protein-3 | ||
| Insulin receptor substrate-1 | ||
| LDL receptor | ||
| *CD44 | ||
| Integrin β1 | ||
| Vascular cell adhesion molecule-1 | ||
| Vimentin | ||
| Cathepsin L | ||
(Table continues)