Table 2A.
Continued
| Genes Up-regulated or Down-regulated in SFK-B Cells Compared to SFK-C Cells | |
|---|---|
| Up-regulation (17 clones) | Down-regulation (22 clones) |
| c-myc proto-oncogene | c-ErbA proto-oncogene |
| Lfc proto-oncogene | Cot proto-oncogene |
| Cyclin B1 | Cdk4/cdk6 inhibitor p18 |
| Cyclin B2 | Prothymosin α |
| Etoposide-induced p53-responsive mRNA | Protein kinase C-θ |
| Glucose regulated protein 78 | *Phosphatidylinositol 3-kinase p85 |
| gp130 | Glutathione peroxidase |
| MAP kinase kinase-1 | Glutathione reductase |
| 14-3-3η | AT motif-binding factor 1 |
| Serine proteinase inhibitor SPI3 | BKLF CACCC box-binding protein |
| Matrix metalloproteinase-11 | Homeobox protein-2.1 |
| MHR23B UV excision repair protein homologue | Homeobox protein-8 |
| Adipocyte differentiation-associated protein | Bone morphogenic protein receptor |
| Transcription factor SEF2 | C5A receptor |
| Integrin β1 | Cannabinoid receptor 2 |
| Laminin receptor 1 | P-selectin |
| Serine protease inhibitor homologue J6 | IGF-binding protein-3 |
| *IGF-I | |
| TGF-β2 | |
| Cytotoxic T lymphocyte-specific serine protease CTLA-1 | |
| *Serine protease inhibitor-2.2 | |
| Serine protease inhibitor-2.4 | |
*The mRNA levels of Eps8, cyclin D1, CD44, phosphatidylinositol 3-kinase (PI3K) p85, IGF-I, and serine protease inhibitor (Spi-2.2) in SFK and SFH cells were also analyzed by Northern blotting as shown in Figure 3A ▶ . Both SFK and SFH cells were maintained for 4 months in vitro before starting the experiments.