Table 2.
Comparison of Data Obtained by Comparative Genomic Hybridization and Fluorescence in Situ Hybridization with Probes for Centromeric Regions of Chromosomes 1 and 6
| Case | WHO type thymoma | CGH rev ish enh | CGH rev ish dim | FISH 1cen number of signals (percentage of cells) | FISH 6cen number of signals (percentage of cells) |
|---|---|---|---|---|---|
| 8 | A | — | −6p21-pter | not done | normal |
| 13 | B3 | +1q | −6 | 4 (19%) | 1 (40%) |
| 13 | B3, R | +1q,+5p,+5cen-q21, +Xq22-qter | −6 | 4 (72%) | 1 (67%) |
| 16 | B3 | +1q | −2 | not done | normal |
| 17 | B3 | +1q | −6 | 4 (50%) | 1 (56%) |
| 22 | B3 | +1q | −6 | 3 (42%), 4 (12%) | 1 (28%) |
| 34 | C(TSCC) | +1q,+5,+18 | −6,−13q, −16q | normal | 1 (91%) |
| 36 | C(TSCC) | +1q,+8,+17q, +18 | −6,−16q,−17p | 3 (14%), 4 (15%) | 1 (32%) |
TSCC, primary thymic squamous cell carcinoma; FISH 1cen, FISH 6cen; fluorescence in situ hybridization with probes for centromeric region of chromosome 1 and 6, respectively; rev ish enh, chromosomal gains detected by CGH; rev ish dim, chromosomal losses detected by CGH. Analysis with centromeric probes of chromosome 11 showed diploidy in all cases examined.