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Examples of genetic alterations of the p53 and DPC4 gene in PILs (P1, P2, P3 = PIL grades 1, 2, 3). Loss of the upper alleles in PILs P2 (lane 4) and P2 (lane 5) at the DPC4 locus. Loss of different alleles of the p53 gene in PILs P3 (lane 5, lower allele; lane 6, upper allele). N, normal; T, tumor.
