Table 4.
Immunohistochemical Staining of p53 Protein in PILs*
| PIL grade | Total | p53 IH(+), LOH | p53 IH(+), n | p53 IH(−), LOH | p53 IH(−), n |
|---|---|---|---|---|---|
| 0 | 13 | 2 (15%) | 11 (85%) | ||
| 1 | 16 | 2 (13%) | 14 (87%) | ||
| 2 | 23 | 2 (9%) | 1 (4%) | 20 (87%) | |
| 3 | 35 | 2 (6%) | 3 (9%) | 10 (28%) | 20 (57%) |
| 4 | 64 | 14 (22%) | 12 (19%) | 11 (17%) | 27 (42%) |
*Compared are results of immunohistochemical staining of PILs (p53IH) with p53 microsatellite analysis of PILs from a corresponding serial tissue section. (+), positive staining of p53 protein ranging from low to high labeling index; (−), negative staining result (<1%) of p53 immunohistochemistry; LOH, loss of heterozygosity; n, normal allele status without detectable LOH.