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Acute Axonal Injury in Normal and Periplaque White Matter of Multiple Sclerosis
| Control white matter | Periplaque white matter (active MS) | Normal white matter (active MS) | Periplaque white matter (inactive MS) | Normal white matter (inactive MS) | |
|---|---|---|---|---|---|
| βAPP-positive axons/0.01 mm2 | 0.05 ± 0.02 | 1.07 ± 0.17 | 0.27 ± 0.09 | 0.07 ± 0.02 | 0.05 ± 0.02 |
| -fold increase compared to control WM | 21.4 | 5.4 | 1.4 | 1 | |
| P values | CO/PP: <0.0001 | CO/NWM: < 0.01 | CO/PP: n.s. | CO/NWM: n.s. |
