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. 2000 Jul;157(1):177–187. doi: 10.1016/S0002-9440(10)64529-4

Figure 2.

Figure 2.

Photomicrographs of representative lungs from WT (n = 6; A−D), Pg−/− (n = 7; E and F), and Pg+/− (n = 7; G and H) mice 14 days after saline or bleomycin treatment. A−C and E−G were stained with Masson’s trichrome; D and H were stained with Prussian blue. A: Saline-treated WT lung showing a bronchiole (b) and artery (a) from the bronchioarterial bundle surrounded by normal deposition of collagen (arrow) and normal alveoli; original magnification, ×100. B: Bleomycin-treated WT lung showing focal areas of fibrosis (f) and proteinaceous exudate (arrows) in the alveolar spaces; original magnification, ×100. C: Another area in the lung in B, showing extensive intra-alveolar hemorrhage (RBCs) and fibrin deposition (arrow); original magnification, ×100. D: Adjacent section to the lung in C showing hemosiderin-laden macrophages (arrows) associated to the area of extensive alveolar hemorrhage; original magnification, ×100. E: Bleomycin-treated Pg−/− lung showing extensive fibrosis (f). No intra-alveolar hemorrhage was observed in the lungs of these animals; original magnification, ×100. F: Higher magnification of the lung in E, showing extensive deposition of collagen (arrows) associated with fibrotic areas (f); original magnification, ×400. G: Bleomycin-treated Pg+/− lung showing both areas of intra-alveolar hemorrhage (h) and fibrosis (f); original magnification, ×100. H: Adjacent section to the lung in G, showing hemosiderin-laden macrophages (arrows) associated with areas of extensive hemorrhage (h) but not with fibrotic areas (f); original magnification, ×100.