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. Author manuscript; available in PMC: 2007 Apr 10.
Published in final edited form as: Arch Biochem Biophys. 2007 Jan 9;458(2):194–201. doi: 10.1016/j.abb.2006.12.023

Table 1.

Inhibition of MTHFS by 5-formylTHF analogs. All reactions were carried out at 37°C in 100mM MES, pH6.0.

Folate analog Ki(μM)
[6R,S]-5-formyl,10-methylTHF 10 ± 1
[6R,S]-5-formyl,10-methylTHFGlu3 20 ± 2
[6R,S]-5-formylTHHF 0.7 ± 0.3
[6R,S]-5-formyl,11-methylTHHF 6.0 ± 3