Table 2.
Histomorphometry Analysis of Distal Femur in 6, 9, and 18-Week-Old eNOS Gene-Deficient (eNOS−/−) and Wild-Type Control (eNOS+/+) Mice
| N* | 6 | 9 | 18 | |||
|---|---|---|---|---|---|---|
| eNOS+/+ | eNOS−/− | eNOS+/+ | eNOS−/− | eNOS+/+ | eNOS−/− | |
| 6 | 8 | 7 | 6 | 6 | 8 | |
| Length† | 14.90 ± 0.10 | 13.94 ± 0.06§ | 14.96 ± 0.20 | 14.43 ± 0.14‡ | 15.70 ± 0.19 | 14.96 ± 0.15‡ |
| BV/TV | 18.99 ± 1.59 | 13.64 ± 0.78‡ | 22.01 ± 1.19 | 12.04 ± 1.27§ | 20.10 ± 2.24 | 14.24 ± 1.73 |
| MTT | 52.92 ± 2.40 | 36.32 ± 1.07§ | 44.88 ± 1.58 | 37.96 ± 3.30 | 43.30 ± 2.06 | 37.57 ± 1.36‡ |
| OV/TV | 0.93 ± 0.18 | 0.57 ± 0.07 | 0.55 ± 0.34 | 0.32 ± 0.17 | 0.30 ± 0.10 | 0.25 ± 0.04 |
| OS/BS | 12.61 ± 1.39 | 8.17 ± 0.79‡ | 6.04 ± 0.69 | 5.25 ± 1.43 | 4.11 ± 1.66 | 3.42 ± 0.36 |
| Ob.S/BS | 7.79 ± 1.35 | 4.38 ± 0.50‡ | 1.75 ± 0.51 | 1.48 ± 0.59 | 0.68 ± 0.22 | 0.30 ± 0.14 |
| ES/BS | 2.90 ± 0.42 | 1.44 ± 0.14‡ | 1.44 ± 0.18 | 1.21 ± 0.39 | 0.90 ± 0.35 | 0.79 ± 0.29 |
| Oc.S/BS | 0.32 ± 0.14 | 0.20 ± 0.25 | 0.25 ± 0.21 | 0.10 ± 0.21 | 0.12 ± 0.09 | 0.03 ± 0.06 |
| MS/OS | 22.32 ± 1.90 | 12.69 ± 1.88‡ | 13.32 ± 1.75 | 9.89 ± 1.14 | 10.20 ± 0.63 | 9.90 ± 1.01 |
| MAR | 1.78 ± 0.07 | 1.50 ± 0.09‡ | 1.37 ± 0.07 | 1.24 ± 0.10 | 0.81 ± 0.02 | 0.72 ± 0.04 |
| BFR/BV | 0.41 ± 0.03 | 0.20 ± 0.02§ | 0.22 ± 0.01 | 0.13 ± 0.02‡ | 0.08 ± 0.01 | 0.07 ± 0.01 |
*Number of mice used per group.
†Length of femur expressed in mm.
‡P < 0.05.
§P < 0.01.
For definitions, abbreviations, and units of measurements, see Table 1 ▶ . Results are means ± SEM.