Table 1.
House-Dust Mite Allergen Sensitization, Exposure, and Procedure Schedule in Adult Rhesus Monkeys
| Time (days) | Procedure |
|---|---|
| 0 | 12.5 mg HDMA in 10 mg A1OH, SQ and 2.5× 1011 killed Boardetella pertussis cell i.m. as adjuvant |
| 14,15,16 | 94 mg HDMA intranasally under anesthesia |
| 30 | 12.5 mg HDMA in 10 mg A1OH, SQ |
| 46 | 94 mg HDMA intranasally under anesthesia |
| 74 | 12.5 mg HDMA in 10 mg A1OH, SQ |
| 105 | Skin testing for HDMA |
| 125 | HDMA aerosol given via facemask |
| 138 | HDMA aerosol challenge |
| 165 | HDMA aerosol challenge |
| 172 | Methacholine aerosol challenge |
| 227–312 | 2–3 hour HDMA aerosol, chamber exposure, approximately every 3 days |
| 243 | Methacholine aerosol challenge |
| 256 | Methacholine aerosol challenge |
| 262 | HDMA aerosol challenge |
| 282 | Methacholine aerosol challenge |
| 289–312 | Necropsy |