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. 2001 Jan;158(1):173–177. doi: 10.1016/s0002-9440(10)63955-7

Figure 1.

Figure 1.

hAPP695 mRNA expression (A and B) and Aβ immunoreactivity (C and D) in Tg2576 (A and C) and PDAPP (B and D) transgenic mice. In situ hybridization in sagittal Tg2576 mouse sections (A) and coronal PDAPP mouse sections (B) demonstrate a neuronal pattern of transgene expression, especially in cortical and hippocampal neuron layers. Bi-3D6 Aβ immunoreactivity in 16-month Tg2576 (C) and 12-month PDAPP (D) mice demonstrate cortical (ctx) and hippocampal Aβ deposits, especially in dentate gyrus (dg) and CA1. Scale bars, 2 mm (A and B) and 500 μm (C and D).