Table 2.
TP53 Mutations in Tumors of the Esophagogastric Junction
| Case | Codon | Base change | Amino acid change |
|---|---|---|---|
| ADCE* | |||
| 1 | 135 | TGC→TTC | Cys-Ser |
| 2 | 220 | TAT→TGT | Tyr-Cys |
| 5 | 230 | ACC→CCC | Thr-Pro |
| 9 | 282 | CGG→TGG (CpG)† | Arg-Trp |
| 12 | 272 | GTG→ATG | Val-Met |
| 283 | CGC→CAC (CpG) | Arg-His | |
| 15 | 157 | GTC→TTC | Val-Phe |
| 16 | 159 | GCC→GTC | Ala-Val |
| 239 | Deletion 13 bp | ||
| 17 | 175 | CGC→CAC (CpG) | Arg-His |
| 18 | 234 | TAC→TAA | Tyr-Stop |
| 19 | 279 | GGG→GGA | Gly-Glu |
| 23 | 213 | CGA→CAA (CpG) | Arg-Glu |
| 24 | 245 | GGC→AGC (CpG)§ | Gly-Ser |
| 25 | 38 | CAA→TAA | Gln-Stop |
| 26 | 237 | ATG→ATA | Tyr-Cys |
| ADCC‡ | |||
| 30 | 213 | CGA→TGA (CpG) | Arg-Stop |
| 32 | 163 | TAC→TGC | Tyr-Cys |
| 33 | 220 | TAT→TGT | Tyr-Cys |
| 38 | 175 | CGC→CAC (CpG) | Arg-His |
| 39 | 213 | CGA→TGA (CpG) | Arg-His |
| 40 | 220 | TAT→TGT | Tyr-Cys |
| 41 | 273 | CGT→TGT (CpG) | Arg-Cys |
| 42 | 282 | CGG→TGG (CpG) | Arg-Trp |
*Adenocarcinoma of the esophagus.
†CpG, pyrimidine dinucleotide repeats.
‡Adenocarcinoma of the cardia.
§CpG site in between codons 244 and 245.