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. 2000 May 16;97(11):5740–5745. doi: 10.1073/pnas.090553997

Figure 5.

Figure 5

Structure of the Nova-2 KH3 domain with the 10021 RNA as presented by Lewis et al. (26). The RNA (bases 1–10 and 16–20 in gray) assumes the predicted hairpin conformation, with AUCAC (A11-C15) responsible for the majority of the contacts with the protein (in white). The colored AUCAC lies in a cleft formed by the KH domain invariant (in light purple) and variable (in light blue) loops; the bases make extensive contacts with an underlying aliphatic α helix/β sheet binding platform.