Figure 1.

FAH mutant animals repopulated with wild-type pancreatic cells. A and B: FAH immunohistochemistry in the liver of FAH mutant mice transplanted with pancreatic cells. A: Small nodule of pancreas derived 4 weeks after transplantation. Original magnification, ×200. B: Almost complete repopulation by pancreas-derived hepatocytes after 8 weeks after transplantation. Only small pockets of mutant tissue (black arrow) remained. Original magnification, ×100. C: Immunohistochemistry with an antibody to glutamine synthetase in a liver extensively repopulated by pancreatic donor cells. Glutamine synthetase was expressed only in zone 3 hepatocytes in the repopulated areas (black arrow), similar to that of normal wild-type control. Original magnification, ×100.