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. 2001 Feb;158(2):571–579. doi: 10.1016/S0002-9440(10)63999-5

Figure 2.

Figure 2.

Y chromosome FISH and β-galactosidase staining of repopulated liver. All sections were from a female FAH− recipient repopulated with male donor pancreatic cells 8 weeks after transplantation. In situ hybridization was performed with a digoxigenin-labeled high-copy number Y chromosome-specific repeat DNA probe. A: Y chromosome FISH of a repopulation nodule. The nuclei of donor-derived hepatocytes are Y chromosome-positive (arrows). B: FAH immunohistochemistry of the same nodule. Original magnification, ×200. C: Whole-mount β-galactosidase staining of FAH mutant liver 4 weeks after transplantation with pancreatic cells. Donor-derived hepatocyte nodules stained blue (arrows).