Table 4.
Results of Corneal Immunostaining for Various Proteinases
| Proteinase* | Increase in diabetic corneas | Increase in DR corneas |
|---|---|---|
| MMP-1, stroma | 0 /10 | 2 /10 |
| MMP-2, stroma | 1 /10 | 0 /10 |
| MMP-3, stroma | 8 /20†‡ | 13 /15†‡> |
| MMP-7, stroma | 0 /10 | 2 /10 |
| MMP-9, stroma, epithelium | 1 /10 | 2 /10 |
| MMP-10 | ||
| Stroma | 5 /10† | 8 /10† |
| Epithelium | 2 /10‡ | 8 /10†‡ |
| MMP-14, stroma | 0 /10 | 2 /10 |
| Cathepsin V/L2, EBM | 0 /10 | 0 /10 |
| u-PA | ||
| Epithelium | 1 /10 | 2 /10 |
| Stroma | 3 /10 | 4 /10 |
| t-PA | ||
| Epithelium (weak) | 1 /10 | 2 /10 |
| Stroma | 3 /10 | 5 /10 |
Number of abnormal cases to total number of cases is shown in each cell.
*Staining localization is included.
†P < 0.05 between diabetic or DR group versus normal.
‡P < 0.05 DR versus diabetic.
EBM, epithelial basement membrane; u-PA, urokinase; t-PA, tissue plasminogen activator.