Table 1.
Summary of Heterozygous Patients with Metastases Demonstrating LOH at the MMP-1 Locus
| Patient no. | Age | Sex | Location of metastasis | Mechanism of spread* | ||||
|---|---|---|---|---|---|---|---|---|
| Loss of 1G allele in metastasis | ||||||||
| 8 | 54 | F | Soft tissue | Lymphatic | ||||
| 14 | 64 | F | Lymph node | Lymphatic | ||||
| 34 | 75 | M | Lung | Hematogenous | ||||
| 38 | 42 | F | Lung | Hematogenous | ||||
| 4 | 75 | F | Lymph node | Unknown† | ||||
| 48 | 71 | M | Lymph node | Lymphatic | ||||
| 53 | 39 | M | Lymph node | Lymphatic | ||||
| 54 | 77 | F | Soft tissue | Lymphatic | ||||
| 61 | 67 | M | Subcutaneous | Lymphatic | ||||
| 65 | 64 | M | Lymph node | Hematogenous | ||||
| Loss of 2G allele in metastasis | ||||||||
| 1 | 38 | M | Lymph node | Lymphatic | ||||
| 22 | 53 | M | Soft tissue | Hematogenous | ||||
*Mechanism of spread was scored as lymphatic if the metastasis was in a lymph node or in soft tissue in the path of lymphatic drainage of the primary tumor; other metastases were scored as hematogenous.
†This was scored as unknown because the location of the primary tumor in this patient was unknown.