Figure 4.

Histological analysis of lung sections after infection with M. tuberculosis (Kurono strain). Lungs were removed from NF-IL-6 KO (a) and WT mice (b) 38 days and 50 days, respectively, after infection with Kurono strain (10 6 CFU) by an airborne route. Hematoxylin and eosin stain; original magnification, ×200. c: NF-IL-6 KO mice infected with Kurono strain were injected subcutaneously three times at day 0 and at weekly intervals with recombinant murine G-CSF (2 μg/mouse). Thirty-eight days later, the mice were sacrificed and the issues were fixed with 10% buffered formalin. Hematoxylin and eosin stain; original magnification, ×200. d: Stain for acid-fast bacilli in the lung of NF-IL-6 infected with Kurono strain. Original magnification, ×600.