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Up-regulation of CA IX/CA XII expression by hypoxia in the glioblastoma cell line, U87. Levels of transcripts under normoxic (N) and hypoxic (H) conditions at different time points were assessed by Northern blot analysis with total RNA samples. After 6 hours of hypoxia an ∼4- and 1.6-fold increase in CA IX and CA XII mRNA expression, respectively, was observed. Twelve hours of hypoxia caused ∼13- and 11-fold up-regulation of CA IX and CA XII, respectively.
