Table 3.
The Distribution of CA IX and CA XII Protein Expression in Normal Adult Human Tissues
| CA IX | CA XII | |
|---|---|---|
| Lining cells of body cavity | ||
| Mesothelial cells (serous membrane) | Diffuse | Focal |
| Coelomic epithelium (surface of the ovary) | Diffuse | Focal |
| Reactive mesothelial cells | Diffuse | Diffuse |
| Underling stellate stromal cells | Focal | Focal |
| Oral cavity/upper respiratory system | ||
| Ductal and mucous cells of submucosal glands | Negative | Focal |
| Ductal cells of salivary glands | Focal | Focal |
| Mucous cells of salivary glands | Negative | Focal |
| Epithelial cells of Schneider’s membrane | Negative | Focal |
| Reactive reserve cells of respiratory epithelium | Rare | Rare |
| Lower respiratory system | ||
| Reactive reserve cells of respiratory epithelium | Rare | Rare |
| Gastrointestinal system | ||
| Gastric pits | Focal | Negative |
| Gastric fundus/pyloric glands | Diffuse | Focal |
| Ductal cells of the Brunner’s glands of the duodenum | Diffuse | Negative |
| Crypt cells of duodenum, small intestine, appendix | Diffuse/Focal | Negative |
| Crypt cells of large intestine | Rare | Negative |
| Surface glandular cells of large intestine | Negative | Focal |
| Pancreas | ||
| Ductal cells | Focal | Negative |
| Acinar cells | Negative | Focal |
| Gallbladder/biliary tract | Diffuse | Negative |
| Genito-urinary system | ||
| Kidney | ||
| Distal convoluted ducts | Negative | Diffuse |
| Intercalated cells of the collecting duct | Negative | Diffuse |
| Renal pelvis | ||
| Transitional cells | Negative | Focal |
| Prostate gland | ||
| Ducts and glands | Negative | Rare |
| Seminal vesicles | Negative | Focal |
| Testis | ||
| Ductular efferens | Diffuse | Diffuse |
| Rete testis | Diffuse | Negative |
| Uterine cervix | ||
| Basal cells of squamous mucosa | Negative | Focal |
| Reactive Reserve cells of the glands | Rare | Rare |
| Uterine endometrial glands | ||
| Proliferative phase | Negative | Focal |
| Secretory phase | Negative | Negative |
| Ovary | ||
| Surface coelomic epithelium | Diffuse | Focal |
| Rete ovarii | Diffuse | Negative |
| Breast | ||
| Lobular and ductal units | Negative | Focal |
| Skin | ||
| Basal cells of epidermis | Negative | Focal |
| Basal cells of hair follicle | Diffuse | Negative |
| Sweat glands | Negative | Diffuse |
| Skeletal system | ||
| Cartilaginous tissues near joint spaces | Focal | Negative |
| Skeletal muscle | Focal | Negative |
| Central nervous system | ||
| Neuron of the cerebellum and cerebrum | Negative | Rare |
| Choroid plexus | Diffuse | Diffuse |
| Lining cells of the ventricle | Focal | Negative |
| Posterior lobe of pituitary gland | Negative | Diffuse |
| Remnant of Rathke’s pouch | Negative | Diffuse |
| Placenta | ||
| Mesodermal cells of amniotic/chorionic plate | Focal | Negative |
| Syncytiotrophoblasts | Negative | Focal |
All normal adult human tissues were examined. Those not listed in the table were negative for both CA IX and CA XII protein expression.
Diffuse, ≥40% of cells within a field stain positively.
Focal, <40% of cells within a field stain positively.
Rare, <5% of cells within a field stain positively.