Figure 1.

Expression of caveolin-1 in normal mesenchymal tissue, benign mesenchymal tumors and sarcomas detected by immunohistochemistry with the monoclonal caveolin-1-specific antibody 2297. A–C: High levels of caveolin-1 protein comparable to normal mesenchymal cells in benign mesenchymal tumors: fibromatosis (A), leiomyoma (B), and lipoma (C). D–G: Reduction of caveolin-1 in sarcomas: fibrosarcoma (D), leiomyosarcoma (E), myxoid liposarcoma (F), malignant fibrous histiocytoma (G). Note caveolin-1-positive endothelial cells within negative tumors (D–G) and single caveolin-1-positive lipoblasts in myxoid liposarcoma (arrow in F). H: High levels of caveolin-1 expression in a subset of sarcomas (malignant fibrous histiocytoma, case 1 in Table 2 ▶ ). I: High levels of caveolin-1 expression in normal mesenchymal tissue (smooth muscle and endothelial cells from stomach). Original magnifications: ×400 (A–G), ×600 (I).