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Fibrin accumulation in livers of mice lacking plasminogen activators. Immunohistochemical staining detects fibrin deposition in injured centrilobular areas in livers of all mice 2 days after CCl4. Acquisition of normal histology is associated with clearance of fibrin in tPA+/uPA+ and tPAo livers, whereas fibrin deposition is a dominant feature in areas of defective repair in uPAo and tPAo/uPAo livers.
