Table 2.
Five-Year Cumulative Probability for Survival and Relapse, and Hazard Ratios from Cox Proportional Hazard Regression Models According to MSI Status
| 5-year cumulative probability (95% CI) | Log-rank test chi-square (P value) | HR* (95% CI) | ||
|---|---|---|---|---|
| MSS/MSI-L (n = 62) | MSI-H (n = 47) | |||
| Survival | ||||
| Stage | ||||
| II | 0.75 (0.59–0.91) | 0.89 (0.77–1.00) | 1.91 (0.2) | 0.33 (0.08–1.31) |
| III | 0.35 (0.19–0.51) | 0.72 (0.51–0.93) | 7.4 (0.006) | 0.29 (0.11–0.76) |
| Overall | 0.53 (0.40–0.65) | 0.82 (0.71–0.93) | 10.77 (0.001) | 0.31 (0.14–0.68) |
| Relapse | ||||
| Stage | ||||
| II | 0.75 (0.57–0.91) | 0.93 (0.83–1.00) | 3.16 (0.08) | 0.23 (0.05–1.15) |
| III | 0.39 (0.22–0.56) | 0.66 (0.44–0.89) | 5.26 (0.02) | 0.35 (0.14–0.89) |
| Overall | 0.55 (0.43–0.68) | 0.82 (0.71–0.93) | 9.59 (0.002) | 0.32 (0.15–0.72) |
*Estimates from separate proportional hazard regression models including terms for sex, age, and stage as appropriate. Reference category was represented by cases MSS/MSI-L.