Table 4.

Hazard Ratios from Cox Proportional Hazard Regression Models According to MSI Status and Number of CD3⁺, CD8⁺, and GrB⁺ IELs Stratified Using Median Value as Cut-Point

	MSS/MSI-L (n = 62)	MSI-H (n = 47)	Overall HR (95% CI)
CD3+ IELs (mean-SD)
Below median (0.03–0.008)	1#	0.22 (0.08–0.65)	1#
Above median (0.07–0.04)	0.32 (0.13–0.79)	0.13 (0.04–0.45)	0.40 (0.19–0.85)
CD8+ IELs (mean-SD)
Below median (0.02–0.007)	1#	0.34 (0.12–0.90)	1#
Above median (0.06–0.04)	0.38 (0.16–0.94)	0.09 (0.02–0.39)	0.33 (0.15–0.73)
GrB+ IELs (mean-SD)
Below median (0.007–0.004)	1#	0.82 (0.33–2.05)	1#
Above median (0.02–0.007)	0.48 (0.19–1.18)	0.09 (0.02–0.35)	0.23 (0.10–0.50)
Overall HR (95% CI)	1#	0.31 (0.14–0.68)

^#, Reference category.

In each cell we reported HR (95% CI) from separate models including terms for age, sex, and stage.