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. 2001 Jul;159(1):109–117. doi: 10.1016/s0002-9440(10)61678-1

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Copyright © 2001, American Society for Investigative Pathology

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Figure 3. — Localization of TGF-βR1 protein in sham-operated and obstructed ovine fetal kidneys. All sections were reacted with anti-TGF-βR1 antibodies. A and C are sections of sham-operated kidneys whereas B and D are from obstructed kidneys. A and B show the outer cortex; C and D show the medulla. Positive immunostaining was not observed in control sections when the primary antibody was omitted (data not shown). A: TGF-βR1 immunoreactivity was detected in ureteric bud tips (u), with low levels in loosely arranged uninduced mesenchyme (m) in sham-operated kidneys. B: Prominent expression of the receptor was detected in the epithelia of dilated ureteric bud branches (u), tubules, and glomerular cysts (g; arrows), and in a subset of surrounding cells, in obstructed kidneys. C: Normal medullary collecting ducts (arrows) expressed TGF-βR1. D: Prominent expression of the receptor was also detected in large abnormally dilated collecting ducts (arrows) in obstructed kidneys. Scale bar, 15 μm.