Table 2.
Chromosome 3p Loss of Heterozygosity in Primary Breast Tumors and Preneoplastic Lesions
| Region | Primary tumor | Preneoplasia* |
|---|---|---|
| 3p25 | 20 /42 (48%) | 3 /31 (10%) |
| 3p22-24 | 27 /44 (61%) | 2 /38 (5%) |
| 3p21.3 | 31 /45 (69%) | 17 /47 (36%) |
| 3p21.2-21.3 | 25 /43 (58%) | 9 /46 (20%) |
| 3p14.3 | 13 /32 (41%) | NE† |
| 3p14.2 | 20 /44 (45%) | 5 /45 (11%) |
| 3p12 | 13 /37 (35%) | NE† |
| Any 3p | 39 /45 (87%) | 21 /47 (45%) |
* Thirteen polymorphic 3p markers were examined in preneoplasia and included: 3p14.2 (D3S1300, D3S4103), 3p21.2-21.3 (D3S1076, D3S1582, ITIH-1), 3p21.3 (D3S4624/Luca2.1, D3S4622/Luca 4.1, D3S4597/P1.5, D3S1447, D3S1478, D3S1029), 3p22-24 (D3S1612), and 3p25 (D3S1597).
†NE = not examined.