Figure 4.

Effects of poly IC and IFN-γ on glucose-stimulated insulin secretion and nitric oxide production by rat islets. Rat islets (220 per ml of complete CMRL-1066) were treated for 48 hours with the indicated concentrations of poly IC, rat IFN-γ, and AG. The islets were isolated and glucose-stimulated insulin secretion was examined (a), and nitrite production (b) was determined on the culture supernatant. Results for insulin secretion and nitrite production are the average ± SEM of three independent experiments.