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Mechanism of dsRNA- and IFN-γ-induced islet cell death. The results presented in this study suggest that dsRNA-induced islet cell apoptosis is dependent on PKR and is associated with normal islet insulin secretion. dsRNA- and IFN-γ-induced islet cell necrosis is dependent on islet production of nitric oxide, is associated with inhibition of insulin secretion, and occurs by PKR-independent mechanisms.
