Table 1.
Immunohistochemical Findings in Dysplasias and Carcinomas
| Lesion | ER-α | ER-β | AR |
|---|---|---|---|
| Dysplasia/peripheral zone | |||
| Moderate grade* | − | + | + |
| High grade | − | − | + |
| Dysplasia/central zone* | + | + | + |
| Carcinoma/peripheral zone | |||
| Grade 3 | −/+ | + | + |
| Grade 4/5 | −/+ | −/+ | + |
| Carcinoma/transition zone | − | − | + |
| Metastatic carcinoma | |||
| Bone | − | + | + |
| Lymph nodes | −/++ | + | + |
*Data reflects positive staining in dysplastic and basal cells. Staining restricted to residual basal cells in high-grade dysplasias. +, Positive staining in >50% of cases; −/++, positive staining in 40% of cases; −/+, positive staining in <20% of cases. See text for estimates of the percent of positively stained cells in each lesion.