Table 2.

Lactate and Pyruvate in Brain and Blood from Control Uninfected, P. berghei ANKA-Infected (CM) and P. berghei K173-Infected (NCM) Mice, and Corresponding Parasitemias

Sample	Parameter	Control	CM (days 6–7)	NCM (days 6–7)	NCM (days 14–22)
Brain	Lactate (μmol/g wet wt)	1.50 ± 0.06	6.38 ± 0.44*	1.50 ± 0.02	1.71 ± 0.06
	Pyruvate (μmol/g wet wt)	0.39 ± 0.02	0.44 ± 0.02	0.40 ± 0.01	0.66 ± 0.03*
	Lactate:pyruvate ratio	3.8 ± 0.1	14.2 ± 0.3*	3.7 ± 0.1	2.6 ± 0.1*
Blood	Lactate (μmol/mL)	5.64 ± 0.08	3.74 ± 0.19*	4.63 ± 0.17	10.06 ± 0.21*
	Pyruvate (μmol/mL)	0.18 ± 0.01	0.16 ± 0.01	0.14 ± 0.05	0.75 ± 0.06*
	Lactate:pyruvate ratio	31.8 ± 1.1	23.6 ± 0.6*	32.4 ± 0.2	12.5 ± 0.5*
	Parasitemia	0	13.2 ± 2.2*	10.1 ± 0.6*	66.2 ± 1.9*

Values are mean ± SEM (n = 5).

*Indicates P < 0.01 (Mann-Whitney U test) compared to uninfected control values.