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. 2001 Sep;159(3):1113–1120. doi: 10.1016/S0002-9440(10)61787-7

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Copyright © 2001, American Society for Investigative Pathology

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Figure 1. — Increased expression of FGF2 in the photoreceptors of transgenic mice does not prevent mutant protein-induced photoreceptor degeneration. Mice that carried one mutant rd allele (rd +/−) showed no evidence of photoreceptor degeneration, whether they carried (B) or did not carry (A) a FGF2 transgene. Mice homozygous for the rd mutation (rd +/+) showed severe photoreceptor degeneration with only one row of photoreceptors remaining at postnatal day (P) 21 whether they carried (D) or did not carry (C) a FGF2 transgene. A total of 10 rd +/+, FGF2 +/− mice were evaluated and all showed a single row of remaining photoreceptors at P21. Mice that expressed a truncated rhodopsin protein in photoreceptors (Q344ter +/−) showed severe photoreceptor degeneration with only one row of photoreceptors remaining at P21 whether they carried (F) or did not carry (E) a FGF2 transgene. A total of 10 Q344ter +/−, FGF2 +/− mice were evaluated and all showed a single row of remaining photoreceptors at P21.