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Quantitative analysis of outer nuclear layer thickness demonstrates significant thinning in the posterior retina of wild-type littermates compared to FGF2 transgenics exposed to 75% oxygen for 2 weeks. FGF2 transgenics (Rho/FGF2; n = 10) and littermate controls (n = 10) were placed in 75% oxygen for 2 weeks and then outer nuclear layer thickness was measured by image analysis at 100 μm from the optic nerve. Statistical comparisons were made by the paired t-test.
