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Cystatin C is increased in AD brain. Temporal lobes of control (A) and AD (B–D) were immunostained for cystatin C. Cortex showed no staining in the control case (A), but strong staining of layer III and V pyramidal neurons in AD brain (B). Cystatin C was also strongly present in neurons of CAI (C) and entorhinal cortex (D). Original magnifications: ×31 (A and B), ×80 (C and D).
