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. 2001 Sep;159(3):1121–1127. doi: 10.1016/s0002-9440(10)61788-9

Figure 1.

Figure 1.

Representative results of 11q13 LOH in multiple leiomyomata in four MEN1 patients. Polymorphic markers (D11S480, PYGM, D11S449, INT-2) at the MEN1 gene locus. Tumor number corresponds to the tumor number in Table 2▶ : T1, esophageal tumor in patient 1; T2 and T3, esophageal tumors in patient 2; T4 to T6, uterine tumors in patient 3; T7 to T9, lung tumors in patient 4; T10, esophageal tumor in patient 4; T11 to T13, uterine tumors in patient 4. Arrowhead indicates the position of the two alleles. Deletion of the lower allele with marker D11S480 was detected in tumor T1 in patient 1 and in tumors T2 and T3 in patient 2. Deletion of the upper allele with marker D11S480 was detected in tumors T4 and T5 in patient 3. For marker PYGM, deletion of the lower allele was seen in tumors T2 and T3 in patient 2 (PYGM(CAGA)) and T11 to T13 in patient 4 (PYGM(AT)). Tumors T7, T8, T10 in patient 4 showed retention of heterozygosity with PYGM. For marker D11S449, the lower allele was deleted in T2 and T3 in patient 2. In patient 4, tumors T11 and T13 demonstrated loss of the lower allele, whereas tumors T7 to T10, and T12 retained heterozygosity with D11S449. Loss of the lower allele in T2 and T3 in patient 2 is seen with marker INT-2. N, matched normal tissue from each patient.